113009WhyObesityGenes

113009WhyObesityGenes - Why do obesity genes exist What...

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Why do obesity genes exist? What does their existence mean for therapy?
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Eukaryotes from yeast to mammals store triglycerides . Yeast cells stained for TG.
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Perilipins are ancient The Perilipins are part of an ancient family of proteins that interact with the surfaces of intracellular neutral lipid droplets. Family members have been identi±ed in Drosophila melanogaster. Tansey et al. The Central Role of Perilipin A in Lipid Metabolism and Adipocyte Lipolysis. IUBMB Life, 56:7, (2004) 379 - 385.
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Experiment: do obesity genes promote survival from starvation? One cannot compare survival of obesity and lean mice. However, one can compare survival lean wildtype to lean mice heterozygous for obesity mutations. Mice utilized are retired male breeders for obese (leptin = ob) and diabetes (leptin receptor = db) mouse strains.
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Phenotypes at the start of the starvation. No differences were observed between normal (+/+) and heterozygous (ob/+ or db/+) mice from either strain with respect to starting body weights, fed plasma insulin, glucose or liver glycogen concentrations.
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Retired male breeders.
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113009WhyObesityGenes - Why do obesity genes exist What...

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