CHEM153A_midterm2_S09_answers

CHEM153A_midterm2_S09_answers - Chemistry 153A, Spring 2009...

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Chemistry 153A, Spring 2009 Midterm 2, Exam A – Answer Key 2. True or False? a. True b. False. The rate of the reaction may vary based on the enzyme’s ability to lower the activation energy. c. True d. True e. False. In an open system, substrates may be continuously added and products may be continuously removed – like in living organisms. f. True g. False. Only proteases that become functional after proteolytic cleavage are zymogens. h. True i. False. Depending on the mechanism, aspartate provides electrostatic stabilization or participates in covalent catalysis. j. True 3. a. 2, 5 b. 1,4 c. 3 4. a. The binding of substrate to chymotrypsin would be unaffected (or minimally affected) because asparagine is similar in size, shape, and polarity to aspartate, so the active site won’t change much; also, the substrate doesn’t directly contact this amino acid b. The activity of chymotrypsin would be disrupted (or greatly diminished) because although asparagine could H-bond to histidine, without aspartate’s negative charge,
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CHEM153A_midterm2_S09_answers - Chemistry 153A, Spring 2009...

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