Answer6 - MCB 161 Lecture 6: DNA Repair Study Problems 5-70...

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MCB 161 Study Problems Lecture 6: DNA Repair 5-70 False. Repair of damage to a single strand by base excision repair or nucleotide excision repair, for example, depends on just the two copies of genetic information contained in the two strands of the DNA double helix. By contrast, precise repair of damage to both strands of a duplex—a double-strand break, for example—requires information from a second duplex, either a sister chromatid or a homolog. 5-73 The statement is incorrect. DNA defects introduced by deamination and depurination reactions occur spontaneously. They do not arise from replication errors and are therefore equally likely to occur on either strand. If DNA repair enzymes recognized such defects only on newly synthesized DNA strands, half of the defects would go uncorrected. Also there is no fundamental reason to link such repair events to replication. The bases produced by deamination and depurination are distinct from the normal bases and can be recognized in any sequence context. By contrast, misincorporation during replication
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This note was uploaded on 03/02/2010 for the course MCB 161 taught by Professor Stacey during the Winter '10 term at UC Davis.

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Answer6 - MCB 161 Lecture 6: DNA Repair Study Problems 5-70...

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