Unformatted text preview: III. Types of mutations and their causes A. Mismatched bases B. Chemically modified bases (hydrolysis, alkylation, oxidation, UV damage) C. Double-strand breaks (oxidation, ionizing radiation) IV. Repair mechanisms A. Mismatch repair - recognition of parental vs newly-replicated DNA strand B. Chemically modified bases i. Direct repair of lesion (e.g. photolyase) ii. Excision repair (removal of one base or of stretch of nucleotides)...
View Full Document
This note was uploaded on 03/02/2010 for the course MCB 161 taught by Professor Stacey during the Winter '10 term at UC Davis.
- Winter '10