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Unformatted text preview: (HDAC, closed chromatin) 2. Chromatin remodeling (SWI/SNF) 3. DNA methylation, histone methylation B. Recruit components of basal apparatus, or stabiliz e interaction of basal apparatus with minimal promoter region (may require mediator complex). C. Activate basal apparatus. D. Compete for binding sites with repressors/activators. III. Myc/Mad/Max mechanism of action A. Mad-Max dimer recruits co-repressors, SIN3A and HDAC2 (histone deacetylase) - represses gene expression B. Myc-Max dimer recruits proteins including histone acetylases - promotes gene expression Lecture 13 MCB 161 S. Harmer 2/15/09 Figure 3 CKII = phosphorylation site (Casein kinase II can phosphorylate) BR = basic region HLH = helix loop helix LZ = leucine zipper AR = acidic region Figures are from: Blackwood & Eisenman (1991) Science, 251 : 1211-1217 (assigned reading)...
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This note was uploaded on 03/02/2010 for the course MCB 161 taught by Professor Stacey during the Winter '10 term at UC Davis.
- Winter '10