Problem15

Problem15 - MCB 161 Lecture 17: Alternate splicing and...

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MCB 161 Study Problems Lecture 17: Alternate splicing and splice regulation S. Harmer The below problem and MBOC problem 7-112. 1. The diagram below illustrates the alternative splicing of a newly discovered mouse gene called JAVA . Alternative splicing of the JAVA transcript produces one mRNA in the stomach and another in the brain as indicated by the lines linking exons (boxes, each numbered below). Sequence elements in the introns that have been shown to be involved in regulation of this alternative splicing are indicated by U 8 C (the sequence UUUUUUUUC) and Pu-rich (a purine rich region). These sequences have been shown to bind specific proteins which regulate the alternative splicing. Answer the questions below. A. (3) Proteins which regulate splicing of JAVA are most likely to reside in (circle one): a) the cytosol b) the nucleus c) the nucleolus d) mitochondria e) the plasma membrane f) histones B. (6) Describe two functional domains you would expect to find in the regulatory
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This note was uploaded on 03/02/2010 for the course MCB 161 taught by Professor Stacey during the Winter '10 term at UC Davis.

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Problem15 - MCB 161 Lecture 17: Alternate splicing and...

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