BIS104 Slide7

BIS104 Slide7 - % correct [% of (your score/120)] Number of...

Info iconThis preview shows pages 1–17. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: % correct [% of (your score/120)] Number of students A+ A B+/A- B-/B/B+ C+/B- C-/C/C+ F/D/C- F Tentative grade range Highest score: 114 Lowest score: 20 Mean score: 71.65 F F Lecture 7 Cell-cell interactions 1. G protein-linked (coupled) Receptors Different ways to pass a signal across the membrane… We will first discuss membrane receptor mediated (transmitted) signaling Membrane receptor mediated signaling Figure 15-1 Molecular Biology of the Cell (© Garland Science 2008) Three major classes of cell surface receptors Figure 15-16 G-protein linked receptors Represent the largest family of cell surface receptors respond to a variety of signals (respond to hormones neurotransmitters etc.) G-protein receptors -consist of a single polypeptide chain which crosses membrane 7 times Serpentine receptor Figure 15-30 Molecular Biology of the Cell (© Garland Science 2008) Figure 15-31 Molecular Biology of the Cell (© Garland Science 2008) Trimeric G proteins Figure 15-32 Molecular Biology of the Cell (© Garland Science 2008) After activating its target protein, the G α shuts off itself by GTP hydrolysis Binding to RGS or target proteins enhances G α-GTP hydrolysis RGS : regulator of G protein signaling-> G α specific GAPs Figure 15-51 Molecular Biology of the Cell (© Garland Science 2008) Receptor desensitization: G-protein receptor kinases ( GRKs ) phosphorylate receptors -Phosphorylated receptors have higher affinity for Arrestin- Arrestin function as adaptors to couple the receptor to clathrin coated pits on PM (receptor-mediated endocytosis) Activation/inactivation of G protein receptors Trimeric G proteins typically activate downstream targets by creating an intracellular second messenger: cyclic-AMP or Ca 2+ The synthesis of cAMP Figure 15-34 Molecular Biology of the Cell (© Garland Science 2008) Figure 15-36 (part 1 of 2) Molecular Biology of the Cell (© Garland Science 2008) An example of G...
View Full Document

This note was uploaded on 03/02/2010 for the course ECL 242 taught by Professor Holly during the Winter '10 term at UC Davis.

Page1 / 42

BIS104 Slide7 - % correct [% of (your score/120)] Number of...

This preview shows document pages 1 - 17. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online