BIS104 Slide8

BIS104 Slide8 - Three broad classes of cell surface...

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Figure 15-16a Molecular Biology of the Cell (© Garland Science 2008) Three broad classes of cell surface receptors that transmit extracellular signals to the inside of cell Acetylcholine-activated Na + channels on muscle cells at the neuromuscular junction
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Figure 15-16b 1. Gs/Gi proteins associated receptors --cAMP levels --PKA activity (transcription, release energy. etc) 2. Gq associated receptors -PLC- β IP3-gated Ca 2+ channel (ER) Three broad classes of cell surface receptors that transmit extracellular signals to the inside of cell
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Their cytosolic domains either has an intrinsic enzyme activity or associate directly with an enzyme
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Six classes of enzyme-coupled receptors 1. Receptor tyrosine kinases 2. Tyrosine kinase associated receptors 3. Receptor-like tyrosine phosphatases 4. Receptor Serine/Threonine kniases 5. Receptor guanylyl cyclases 6. Histidine kinases associated receptors Most of these receptors possess enzymatic activities related to phosphorylation ( kinase or phosphatase )
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Receptor tyrosine kinase receptors (Receptors that are tyrosine kinases) Figure 15-16c Molecular Biology of the Cell (© Garland Science 2008) Three broad classes of cell surface receptors that transmit extracellular signals to the inside of cell
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Figure 15-53a Molecular Biology of the Cell (© Garland Science 2008) Receptor tyrosine kinases Many are receptors for growth factors Function as a dimer
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Seven subfamilies of receptor tyrosine kinases (RTKs) Many are receptors for growth factors Figure 15-52 Molecular Biology of the Cell (© Garland Science 2008)
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Many RTKs are receptors for growth factors Table 15-4 Molecular Biology of the Cell (© Garland Science 2008) Details are FYI
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Signal molecules are bound to cell surface (immobilized) Signaling is bi-directional: Ephrins and Eph receptors can act as both ligand and receptor Helps to guide cell migration and axon extension -important in the development of CNS Eph receptors are the most numerous receptor tyrosine kinases
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Ligand binding Catalytic domain Growth factor Dimerization How do growth factors activate Receptor tyrosine kinases?
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This note was uploaded on 03/02/2010 for the course ECL 242 taught by Professor Holly during the Winter '10 term at UC Davis.

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BIS104 Slide8 - Three broad classes of cell surface...

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