BIS104 Slide13

BIS104 Slide13 - Tentative grade range(MT2 C/C/B B/B Number...

Info iconThis preview shows pages 1–13. Sign up to view the full content.

View Full Document Right Arrow Icon
A+ A B+/A- B/B+ C /C+/B- C-/C D/C- F % correct [% of (your score/120)] Number of students Tentative grade range (MT2) Highest score: 118 Lowest score: 24 Mean score: 77.44
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
1. Cell cycle- the cast of players and checkpoints 2. Apoptosis Lecture 13
Background image of page 2
Figure 17-1 Molecular Biology of the Cell (© Garland Science 2008) Overview-cell cycle Cell cycle : repeated rounds of cell division and growth
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
The phases of cell cycle Figure 17-4 Molecular Biology of the Cell (© Garland Science 2008)
Background image of page 4
Organisms must coordinate cell replication 1. single cell organisms: replicate themselves in response to growth conditions (environment) 2. multicellular organisms: cells replicate during embryogenesis, and to replace wear and tear Must decide to replicate or not to replicate Once decided, must coordinate the necessary molecular events to happen at correct time and in correct order Overview - cell cycle
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
G0 Quiescent M (mitosis) G1 S (DNA synthesis) G2 These events must take place in correct order (ex. terminally differentiated cells) signals Cycling
Background image of page 6
Figure 17-14 Molecular Biology of the Cell (© Garland Science 2008) G1 checkpoint G2/M checkpoint Late M checkpoint
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
G1 S (DNA synthesis) G2 M (mitosis) G1 checkpoint Is M complete? Is cell big enough Is environment favorable? Cell cycle is regulated by a central control system - Checkpoints : function by timing and monitoring each step
Background image of page 8
G1 S (DNA synthesis) G2 M (mitosis) Cycling G2/M checkpoint Is all DNA replicated?
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
G1 S (DNA synthesis) G2 M (mitosis) Cycling Late M checkpoint (metaphase to anaphase transition) Are all chromosomes on mitotic spindle?
Background image of page 10
Cell cycle control: mediated by protein kinase/cyclin complexes Serine/Threonine kinases Protein 1 needed for S phase P Protein 2 needed for S phase P Protein 3 needed for M phase Etc. P In yeast, one type of Cdk responsible for all parts of the cell cycle In higher eukaryotes, multiple Cdks each responsible for different events
Background image of page 11

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Protein 1 needed for S phase P Protein 2 needed for S phase P Protein 3 needed for M phase Etc. P
Background image of page 12
Image of page 13
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

Page1 / 56

BIS104 Slide13 - Tentative grade range(MT2 C/C/B B/B Number...

This preview shows document pages 1 - 13. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online