BIS104 Slide14 - Lecture 14 Apoptosis Control of Cell...

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Lecture 14: Apoptosis , Control of Cell Growth and Cancer
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G1 S G2 M (mitosis) Cycling Apoptosis Apoptosis-programmed cell death
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Apoptosis is essential during development -help to shape the morphology of the organism Developing mouse paw Metamorphosis of a tadpole Figure 18-2 and 18-3 Molecular Biology of the Cell (© Garland Science 2008)
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Apoptosis: to get rid of potentially harmful cells 1. Immune cells that would react to self-antigens are programmed to die during fetal development 2. Cells that display signs of uncontrolled/unbalanced growth and differentiation---> cancer cells
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Figure 18-1 Molecular Biology of the Cell (© Garland Science 2008) Necrosis -accidental death Apoptosis Exploded/lysised Characteristics of cells undergo apoptosis: cell swells, remains intact, nucleus condense, DNA fragmented, large vacuoles
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Mechanisms of apoptosis - Caspases
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Figure 18-5a Molecular Biology of the Cell (© Garland Science 2008) Each suicide protease is made as an inactive pro-caspase -activated by proteolytic cleavage by another member of the caspase family
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Figure 18-5b Molecular Biology of the Cell (© Garland Science 2008)
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Figure 18-6 Molecular Biology of the Cell (© Garland Science 2008) Death signals mediated by cell surface receptors -extrinsic death signal Fas and Caspase 8 or 10
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Death signals mediated by cytochrome C -intrinsic death signal Cytochrome C and Caspase- 9 Figure 18-8 Molecular Biology of the Cell (© Garland Science 2008)
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Figure 18-11a Molecular Biology of the Cell (© Garland Science 2008) Pro-apoptotic protein Bax activates apoptosis Bax
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Figure 18-11a Molecular Biology of the Cell (© Garland Science 2008) Anti-apoptosis protein Bcl-2 inhibits apoptosis Bax
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Figure 18-11b Molecular Biology of the Cell (© Garland Science 2008) BAD BAX
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Figure 15-64 Molecular Biology of the Cell (© Garland Science 2008) Regulation of cell survival/apoptosis Bcl2 Bcl2
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Control of cell growth What triggers a cell to replicate: G 0 -> G1 control
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