Homework8Solution - that is antiparallel directions What is...

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Biology 214/414 Homework #8 Due 10-16-09 DNA polymerase III, the main DNA synthesizing enzyme in bacteria is remarkable, but it does have some limitations. What is the limitation (or peculiar property) of DNA polymerase III that results in semi- discontinuous DNA replication (that is the leading and lagging strands having to be synthesized in different overall directions with respect to the direction of movement of the replication fork)? The ability of DNA polymerase III to be able to synthesize new DNA only in the 5’ to 3’ direction (combined with the fact that the two single strands of DNA must go in opposite,
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Unformatted text preview: that is, antiparallel directions). What is the limitation (or peculiar property) of DNA polymerase III that results in the need for RNA primers to be synthesized to serve as the initial “growing points” for DNA synthesis? DNA polymerase cannot begin a new DNA strand from the very first nucleotide, that is, it cannot put in the first nucleotide in a new DNA polymer. It is able only to extend an existing primer of RNA or DNA....
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