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Unformatted text preview: without being folded in some way? Why or why not? The amount of DNA in a core particle is 146-147 bp; for simplicitys sake, lets call it 146 bp. Then the length of DNA in the average nucleosome is 146 + 50 = 196 bp. Thus, the total number of nucleosomes in one copy of chromosome 21 is (4.5E7 bp)/(1.96E2 bp/nucleosome) = 2.3E5. If each is 6 nm tall, then the length of the entire stack is (6 nm/nucleosome)(2.3E5 nucleosomes) = 1.38E6 nm = 1.38 million nm =1380 m. A typical human nucleus is about 5 m in diameter, so that considerable folding in addition to that in the nucleosomes themselves is essential....
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- Spring '06