lecture 37 notes - Lecture 37: Learning and Memory 10781080...

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Lecture 37: Learning and Memory 1078-1080 1125-1129 49.4 Changes in Synaptic Connections Underlie Memory and Learning -during embryonic development, regulated gene expression and signal transduction establish  overall structure of nervous system -2 processes then dominate the remaining development of the nervous system 1) Competition among neurons for survival:  neurons compete for growth-supporting  factors which are produced in limited quantities by tissues that direct neuron growth -cells that don’t reach the proper locations fail to receive such factors and undergo  programmed cell death…half of the neurons formed in embryo die -effect: preferential survival of neurons that are located properly within nervous system 2) Synapse Elimination : a developing neuron forms numerous synapses (more than  required), activity of that neuron than stabilizes some synapses and destabilizes others  and by the end of embryogenesis, neurons have lost more than half of their initial  synapses, leaving behind the connections that survive into adulthood -both set up network of cells and connections within the nervous system Neural Plasticity -CNS can change after birth…the capacity for the nervous system to be remodeled, especially in  response to its own activity is called  neural plasticity -much of the reshaping of the nervous system occurs at synapses -when activity at a synapse correlates with that of other synapses, changes may occur that  reinforce that synaptic connection -when the activity of a synapse fails to correlate with that of other synapses, the synaptic  connection sometimes becomes weaker
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lecture 37 notes - Lecture 37: Learning and Memory 10781080...

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