2.Secretory Pathway 2010

2.Secretory Pathway 2010 - N-Terminal sequences of some...

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N-Terminal sequences of some eukaryotic secretory preproteins Voet/Voet Fig. 12-46 What strikes you about these signal sequences?
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Basic organization of human SRP Biochim Biophys Acta. 2004 Nov 11;1694(1-3):17-35. SRP SRP receptor on membrane SRP RNA – black line Note the two domains of SRP – Alu and S domains
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Ribosomal synthesis, membrane insertion, and initial glycosylation of an integral protein via the secretory pathway Voet/Voet Fig. 12-45 Possible protein blocking translocon when not in use – BiP?
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Nissen et al. Science , 289 (2000) 920-930 The nascent chain exits through the back of the large subunit PT = peptidyl transferase center on the interface side of the large subunit
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Halic et al. Nature 427 (2004) 808-814 Interaction of SRP with the ribosome Translation arrest mediated by this region of SRP Signal sequence recognized by SRP54 near the exit tunnel
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Ribosomal synthesis, membrane insertion, and initial glycosylation of an integral protein via the secretory pathway Voet/Voet Fig. 12-45 Possible protein blocking translocon when not in use – BiP?
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Structure of Sec61 interacting with the ribosome Voet/Voet Fig. 12-50a
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2.Secretory Pathway 2010 - N-Terminal sequences of some...

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