4.Introduction to Metabolism posted 2010 post

4.Introduction to Metabolism posted 2010 post - O=C R R N R...

Info iconThis preview shows pages 1–9. Sign up to view the full content.

View Full Document Right Arrow Icon
Background Material on Metabolism You are Responsible for 1. Review the nomenclature of organic cpds and their relative oxidation state. 2. Review organization and structure of cells -Voet and Voet p. 1-13. 3. Review classes of enzymes - Table 13-3 4. Review allosteric model for enzyme regulation - Voet and Voet p. 465-469 5. Metabolism - an overview - Voet and Voet Chapter 16 6. Review roles of coenzymes in metabolic reactions - Voet & Voet Chapter 13 p. 463-465.
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Metabolic pathways are complex and integrated Voet/Voet Fig. 16-1
Background image of page 2
Types of metabolic group-transfer reactions. Acyl group transfer Voet/Voet Fig. 16-6a
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
The phosphoryl- transfer reaction catalyzed by hexokinase. Voet/Voet Fig. 16-7
Background image of page 4
Oxidation–reduction reactions with NAD + B: + H-O-C-H R R' + N C NH 2 O H R B-H
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 6
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 8
Background image of page 9
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: + + O=C + R R' N R H H C NH 2 O general base alcohol general acid NAD + NADH aldehyde Note that this is a hydride transfer + B: + H + Group on enzyme Group on enzyme Flavin adenine dinucleotide (FAD) Voet/Voet Fig. 16-8 Mechanism of aldol/keto isomerization . Voet/Voet Fig. 16-6a Stabilizing carbanions Voet/Voet Fig. 16-12 Carbanions adjacent to carbonyl groups hydrogen bonded to general acids are stabilized electrostatically or by charge neutralization. Carbanions adjacent to carbonyl groups are stabilized by the formation of enolates Stabilizing carbanions Carbanions adjacent to protonated imines (Schiff bases) are stabilized by the formation of enamines. Metal ions stabilize carbanions adjacent to carbonyl groups electrostatically...
View Full Document

This note was uploaded on 03/03/2010 for the course CHEM 431 taught by Professor Pielak during the Spring '07 term at UNC.

Page1 / 9

4.Introduction to Metabolism posted 2010 post - O=C R R N R...

This preview shows document pages 1 - 9. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online