5.Glycolysis 2010

5.Glycolysis 2010 - phosphate dehydrogenase The...

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Mechanism of phosphoglucose isomerase. Voet/Voet Fig. 17-6
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Phosphorylation of F6P to F1,6P 2 Voet/Voet/Pratt Chapter 14
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Cleavage of F1,6P 2 into Two Trioses Voet/Voet/Pratt Chapter 14 What reaction class does aldolase fall into? Reactions that make and break carbon- carbon single bonds
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Proposed Mechanism of Aldolase Voet/Voet Fig. 17-9
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Interconversion of Triose Phosphates C-H O HCOH CH 2 OH C O O-PO 3 -2 CH 2 O-PO 3 -2 CH 2 DHAP Ga-3P What intermediate do you expect to see in this reaction? Ene-diolate intermediate – reaction similar to Glu-6P M Fru-6P
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Reaction of Ga-3-P dehydrogenase Voet/Voet Fig. 17-13 What class of reactions is represented here? Oxidation/Reduction Reaction is an oxidation as written. Note that the product is an acid anhydride. What two acids is this anhydride made from? A carboxylic acid and phosphoric acid
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Voet/Voet Fig. 17-14 Mechanism of glyceraldehyde-3-
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Unformatted text preview: phosphate dehydrogenase The phosphoglycerate kinase reaction Voet/Voet Fig. 17-16 Conversion of 3-Phosphoglycerate to 2-Phosphoglycerate Voet/Voet/Pratt Chapter 14 Voet/Voet Fig. 17-18 Mechanism of phosphoglycerate mutase Conversion of 2PG to PEP Voet/Voet/Pratt Chapter 14 Mechanism of enolase Voet/Voet Fig. 17-21 Mechanism of pyruvate kinase Voet/Voet Fig. 17-22 Question in class The term glycolysis refers to the flux of glucose-6P down the degradative pathway we just went through. Gluconeogenesis represents the flow from pyruvate back to Glucose-6P Which two reactions from glycolysis cannot be reversed in gluconeogenesis? 1. Fructose-6P to Fructose-1,6 bisphosphate 2. PEP to pyruvate Since these two reactions are not directly reversible, flow through these pathways can be controlled....
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