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6.PDC-Citric Acid Cycle_2010

6.PDC-Citric Acid Cycle_2010 - Conversion of Citrate to...

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Voet/Voet Fig. 21-2 Chemical structure of acetyl-CoA.
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The five reactions of the PDC. Voet/Voet Fig. 21-6
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PDC Reaction: Step 1
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Structure of thiamine pyrophosphate The H on this carbon is labile and the carbanion formed here attacks C-2 of pyruvate forming a covalent adduct which decarboxylates leaving C2 and C3 attached to TPP
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The five reactions of the PDC. Voet/Voet Fig. 21-6
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Structure of lipoamide Voet/Voet Fig. 21-7 Note covalent attachment to the amine in the side chain of a lysine residue in E 2 The lipoaminde is initially in the oxidized form with the disulfide bond
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PDC Reaction: Step 2
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PDC Reaction: Step 3
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Interconversion of lipoamide and dihydrolipoamide Voet/Voet Fig. 21-7
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PDC Reaction: Steps 4 and 5 The oxidized form of lipoamide must be regenerated FADH - anion probably actual intermediate
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Voet/Voet Fig. 21-1 Reactions of the citric acid cycle .
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Mechanism of the citrate synthase reaction. Voet/Voet Fig. 21-19
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* * * From acetyl-CoA See Voet/Voet Fig. 21-19 for proposed mechanism
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Unformatted text preview: Conversion of Citrate to Isocitrate Citrate appears to be symmetrical but the two CH 2 COO- are treated differently Mechanism of isocitrate dehydrogenase . Voet/Voet Fig. 21-21 Enz B: Hydride to NAD+ V-Ketoglutarate Dehydrogenase Reaction This reaction is analogous to the reaction catalyzed by the PDC complex Reactions catalyzed by succinyl-CoA synthetase. Formation of succinyl phosphate, a “high-energy” mixed anhydride. Voet/Voet Fig. 21-22 H + Reactions catalyzed by succinyl-CoA synthetase. Formation of phosphoryl–His, a “high-energy” intermediate. Voet/Voet Fig. 21-22 Reactions catalyzed by succinyl-CoA synthetase. Transfer of the phosphoryl group to GDP, forming GTP. Voet/Voet Fig. 21-22 Oxidation of Succinate to Fumarate Covalent attachment of FAD to a His residue of succinate dehydrogenase. Voet/Voet Fig. 21-23 Hydration of Fumarate to Malate Oxidation of Malate to Oxaloacetate...
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