2.Protein_stability

2.Protein_stability - Protein Stability Chem 431 Protein...

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Unformatted text preview: Protein Stability Chem 431 Protein Str ucture Prediction KVFERCELARTLKRLGMDG YRGI SLANWMCLAKWESGY NTRATNYNAGDRSTDYGI F QI NSRYWCNDGKTPGAVNA CHLSCSALLQDNI ADAVACA KRVVRDPQGI RAWVAWRN RCQNRDVRQYVQGCGV ? Primary Structure Tertiary Structure Projects such as the Human Genome Project and the Gene Ontology Project have yielded massive amounts of infor mation about genes and the sequences that encode proteins Traditional protein str ucture deter mination is incredibly time consuming Why do we care? Proteins are the building blocks of life Protein function is directly linked to its str ucture Better dr ug development Design novel prot eins Forces that Gover n Protein Stability Understanding the forces that stabilize the structures of proteins we know will lead to us being able to predict the structure of unknown proteins Forces that Gover n Protein Stability (1) van der Waals Forces (1) 1. van der Waals Forces attractive or repulsive force between electr ically neutral molecules 1. van der Waals Forces Energetics of van der Waals forces A single van der Waal interaction is not ver y large, but in a prot ein there are thousands of these int eractions which add up to be a major fact or in prot ein stabilization Forces that Gover n Protein Stability (1) van der Waals Forces (1)Hydrophobic Effects (1) (3) (2) (4) (5) 2. Hydrophobic Effect Oil and Water dont mix Bur y hydrophobic (non polar) residues away from water (polar) Hydropathy Scale for Amino Acid Side Chains 2. Hydrophobic Effect------------- 2. Hydrophobic Effect Hydropathic index plot for bovine chymotrypsinogen: The sum of the hydropathies of nine consecutive residues are plotted versus the residue sequence number....
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2.Protein_stability - Protein Stability Chem 431 Protein...

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