9.Euk RNA Transcription

9.Euk RNA Transcription - Readings in addition to chapter...

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Readings in addition to chapter 31 Chapter 33-3 (bacteriophage lambda) Chapter 34-1 and 34-3 (eukaryotic transcription)
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Lewin Genes VII Fig. 20.2 Subunit composition of eukaryotic RNA polymerases α β β Red = found in all three polymerases
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Lewin Fig. 20.4 Bipartite Pol I promoters
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Lewin Fig. 20.5 Pol III promoters may be downstream of the start site
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Lewin Fig. 20.6 Variations in Pol III promoters 5S rRNA Other small nuclear RNAs tRNA
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Lewin Fig. 20.7 Transcription factors required for Pol III initiation
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http://148.216.10.83/molecular/10_6.htm Assembly of the transcription complex with RNA Pol II TFIIA required in vivo Role ? TBP “identifies” the start site then recruits TAFS to form TFIID Then TFIIF brings RNAPII Then TFIIE and TFIIH TFIIH has helicase activity
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Lewin Genes VII, Fig. 20.9 Model TBP bound to DNA Two larger domains of TBP are in dark and light blue while the N-terminal domain is in green. The two DNA strands are gray and white.
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http://148.216.10.83/molecular/10_6.htm TBP widens the minor groove and bends the DNA
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Lewin Genes VII Fig. 20.12 TFIIB binds the TBP-DNA complex DNA green and yellow TBP blue TFIIB purple and red
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Garrett and Grisham, Biochemistry Fig. 31.37 The Zinc Finger
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Garrett and Grisham, Biochemistry Fig. 31.38 The Zinc finger positions helices so they follow the major groove in the DNA
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Interaction of amino acids side chains with edges of the bases in the major groove of DNA Science 252 (1991) 809-817
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9.Euk RNA Transcription - Readings in addition to chapter...

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