14.Introduction to the Ribosome - Nov17

14.Introduction to the Ribosome - Nov17 - Introduction to...

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Introduction to the Ribosome Chem 431 November 17 2009 Rebekah Nash
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Genetic Code + tRNA + Ribosome DNA RNA Protein Nucleic Acids Nucleic Acids Amino Acids The Process RNA Polymerase
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The Composition of the Ribosome PDB Codes: 2WRJ, 2WRI 1. rRNA 1. Protein 1. Ligands
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PDB Codes: 2WRJ, 2WRI The Composition of the Ribosome
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The Composition of the Ribosome 16S 5S 23S
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Figure 32-27a Secondary structures of the E. coli ribosomal RNAs. ( a ) 16S RNA. Page 1311 Watson-Crick bp G-U bp Non-Watson-Crick bp The 16S rRNA
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Figure 32-27b Secondary structures of the E. coli ribosomal RNAs. ( b ) 23S and 5S RNAs . Page 1311 The 23S and 5S rRNA
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PDB Codes: 2WRJ, 2WRI The Composition of the Ribosome
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Figure 32-34a Gallery of ribosomal protein structures. ( a ) Proteins from the 30S subunit. Page 1315
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PDB Codes: 2WRJ, 2WRI The Composition of the Ribosome
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Figure 32-29 X-Ray structures of two ribosomal proteins. ( a ) The 74-residue C-terminal fragment of E. coli L7/L12. ( b ) Bacillus stearothermophilus L30 (61 residues). Page 1312 Two RRMs from Different L Proteins The RNA Binding Motifs
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The Svedberg A measure of sedimentation rate Larger particle sedimentation rate increases larger Svedberg (S) NOT additive Dependent on both mass and volume of particle Loss of surface area occurs when two particles bind to form one
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PDB Codes: 2WRJ, 2WRI The Composition of the Ribosome 1. Large Subun it(50S) 2. Small Subun it (30S)
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PDB Codes: 2WRJ, 2WRI The Composition of the Ribosome The Small Subunit (30S) 1.rRNA = 16S 2.Protein = 21 total
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PDB Codes: 2WRJ, 2WRI The Composition of the Ribosome Head Body Platform 90 ˚
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PDB Codes: 2WRJ, 2WRI The Composition of the Ribosome The Large Subunit (50S) 1.rRNA = 23S, 5S 2.Protein = 31 total
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PDB Codes: 2WRJ, 2WRI The Composition of the Ribosome Central Protuberance Stalk Ridge/Wing Valley 90 ˚
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PDB Codes: 2WRJ, 2WRI The Composition of the Ribosome Central Protuberance Stalk Ridge/Wing Valley
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PDB Codes: 2WRJ, 2WRI The Composition of the Ribosome Central Protuberance Stalk Ridge/Wing Valley Head Body Platform
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This note was uploaded on 03/03/2010 for the course CHEM 431 taught by Professor Pielak during the Spring '07 term at UNC.

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14.Introduction to the Ribosome - Nov17 - Introduction to...

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