103Lect4Sp08powerpoint

103Lect4Sp08powerpoint - T y p o p ag e 1 4 ....

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Typo page 14. GLYCERALDEHYDE-3-P DEHYDROGENASE MECHANISM Glycolysis, step 6
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H CHO OH H HO OH H OH H CH 2 OH H CHO OH H HO OH H OH H CH 2 OPO 3 2- GLC-6-P GLC ATP ADP CH 2 OH O H HO OH H OH H CH 2 OPO 3 2- ATP ADP CH 2 OPO 3 2- O H HO OH H OH H CH 2 OPO 3 2- CH 2 OPO 3 2- O CH 2 OH H HC OH CH 2 OPO 3 2- + HPO 4 2- NAD + NADH H C OH CH 2 OPO 3 2- O OPO 3 2- ATP ADP H C OH CH 2 OPO 3 2- O - O H C OPO 3 2- CH 2 OH O - O C OPO 3 2- CH 2 O - O C O CH 3 O - O ATP ADP F-6-P DHAP G-3-P 1,3 bisPGA 3-PGA 2-PGA PEP PYR H 2 O 1 2 3 4 5 6 7 8 9 10 on a per glucose basis, from here multiple all by 2 H O OH H OH H OH CH 2 OH OH H O OH H OH H OH CH 2 OPO 3 2- OH ATP ADP 1 2 O 3 POH 2 C OH CH 2 OH H OH H H OH O O 3 POH 2 C OH CH 2 OPO 3 2- H OH H H OH O ATP ADP 3 Fischer projection-open chain Ring form O F-1,6-bisP + H + 1 2 3 4 5 6 1 2 3 4 5 6 1,6 2,5 3,4 Haworth projection [ 11 ] Aerobic Glycolysis HB pg 11
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1 GLC + 2 ATP 2 G-3-P + 2 ADP 1 GLC + 2ADP + 2Pi + 2NAD + 2 PYR + 2 ATP + 2NADH + 2H 2 O 2 G-3-P + 2Pi + 4 ADP + 2 NAD + 2 PYR + 4 ATP + 2NADH + 2H 2 O Summary of 10 steps into 2 phases 1.Costs ATP to make ATP! 2. For flux through glycolysis to continue, need to recycle NADH back to NAD+ Done different ways- HB pg 17 Steps 1-5 Steps 6-10
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C O CH 3 O -O C H CH 3 O -O PYR HO LACTATE LACTIC ACID FERMENTATION 11 NADH + H + NAD + FINAL STEPS OF TWO DIFFERENT FERMENTATION PATHWAYS Where and when does lactic acid fermentation occur? 1. Mammalian cells, almost all cells, mostly in skeletal muscle, mature red blood cells, cardiac muscle- 2. Plant roots, usually not leaves 3. Certain bacteria- eg., Lactobacilli (yogurt), Streptococcus mutans- anaerobic bacteria in mouth-lactic acid lowers pH, which dissolves enamel HB pg 17 LDH Lactate dehydrogenase Partial list:
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C O CH 3 O -O O CH 3 H CH 2 OH CH 3 PYR ALCOHOLIC OR ETHANOLIC FERMENTATION 12 ACETALDEHYDE ETHANOL 13 NADH + H + NAD + CO 2 FINAL STEPS OF TWO DIFFERENT FERMENTATION PATHWAYS Where and when does ethanolic fermentation occur? 1. Plant roots, typically not leaves 2. Certain microbes- yeasts 3. NOT in Humans -do not have pyruvate decarboxylase, cannot do ethanolic fermentation- BUT Catabolism of ethanol does occur in human liver- Humans do have ADH ADH PDC HB 17
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Anaerobic Glycolysis is an Internal Oxidation-Reduction Process C OH CH 3 O -O H LACTATE C OH CH 3 O -O H CHO OH H H HO OH H OH H CH 2 OH GLC 1 2 3 4 5 6 1 2 3 4 5 6 In toto, there is no net oxidation-reduction of the carbons HB pg 18
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103Lect4Sp08powerpoint - T y p o p ag e 1 4 ....

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