103Lect5powerpt

103Lect5powerpt - In Praise of EMP (= Glycolysis ) sung to...

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Unformatted text preview: In Praise of EMP (= Glycolysis ) sung to the tune of "The British Grenadier" Some pathways lead to glory like Hatch and Slack and Knoop, Utter, Calvin, Cori a most distinguished group But of all the nature's pathways we sing the praises today of Parnas, Embden, Meyerhof the glycolytic way Glucose by hexokinase is turned to G-6-P you might use glucokinase you must use ATP And note, glycogenolysis(when stores are in the cell) its G-1-P which then mutates to G-6-P as well. A moiety of glucose in the succeeding phase is transferred to a ketose by an isomerase PFK now acts on that F-6-P F1,6 bisP is the product that’s set free. The kinase is affected complicatedly and as you'll have suspected it uses ATP. F-B-P by aldolase is split reversibly to phoshoglyceraldehyde, also DHAP. The former and latter can each equilibrate It really doesn’t matter for metabolic fate. So follow PG-aldehyde and double what you see. You'll get the total balance sheet for hexose moeity. There’s now a novel facet, for NAD's reduced. A carboxylic acid is not what is produced Delta E substantial and energy’s conserved for otherwise the pathway would quite frankly be absurd. Complex oxidation of PG-aldehyde gives by phosphorylation an acid anhydride and that bisphosphoglycerate reacts with ADP the kinase making ATP, of course reversibly. The products composition is 3-phosphoglycerate from three to two position can readily mutate and now two phosphoglycerate does something rather strange the electrons on C2 and 3 proceed to rearrange The redox dehydration catalyzed by enolase gives PEP formation, and bond energy is raised so PEP reacts with ADP the kinase making ATP, but not reversibly in anaerobiosis pyruvate is not the end...
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This note was uploaded on 03/04/2010 for the course BIS 103 taught by Professor Abel during the Spring '08 term at UC Davis.

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103Lect5powerpt - In Praise of EMP (= Glycolysis ) sung to...

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