103Lect8powerpoint

103Lect8powerpoint - Lecture 8 T h e P e n to s e P h o s p...

Info iconThis preview shows pages 1–5. Sign up to view the full content.

View Full Document Right Arrow Icon
Lecture 8 The Pentose Phosphate Pathway or There’s more than one way to catabolize glucose And How do cells organize all these pathways (part 1)?
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
H O OH H OH H OH CH 2 OPO 3 2- H O OH H OH H OH CH 2 OPO 3 2- O H COO - OH H HO OH H OH H CH 2 OPO 3 2- H COO - OH O OH H OH H CH 2 OPO 3 2- H H C OH O OH H OH H CH 2 OPO 3 2- OH NADP + NADPH + H + H 2 O NADP + NADPH + H + CO 2 + GLC-6-P 6-phosphoglucono- ! - lactone 6-phosphogluconate Ribulose-5-P I. Pentose Phosphate Pathway 1 2 3 3 H + HB 42 Also known as: hexose monophosphate shunt, Oxidative PPP, phosphogluconate pathway Beta keto acid Beta-OH acid Oxidative phase Cytosolic, in mammalian cells the flux through this pathway is high in liver and adipose, low in muscle
Background image of page 2
H H C OH O OH H OH H CH 2 OPO 3 2- HC O OH OH H OH H CH 2 OPO 3 2- H H C OH O OH H OH H CH 2 OPO 3 2- H H C OH O H HO OH H CH 2 OPO 3 2- H Ribulose-5-P Ribulose-5-P Ribose-5-P Xylulose-5-P (X-5-P) II. 4 5 Pentose Phosphate Pathway HB 42 Isomerization phase (a non oxidative phase) ketolisomerase epimerase To balance the cycle- synthesize 3 Ribulose-5-P Convert 2 to X-5-P and 1 to R-5-P x2 Whole point of epimerization is to Produce a ketose (X-5-P) with trans configuration
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
H H C OH O H HO OH H CH 2
Background image of page 4
Image of page 5
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 03/04/2010 for the course BIS 103 taught by Professor Abel during the Spring '08 term at UC Davis.

Page1 / 18

103Lect8powerpoint - Lecture 8 T h e P e n to s e P h o s p...

This preview shows document pages 1 - 5. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online