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103Lect10powerpoint - Lecture 10 PPP song Enzyme Regulation...

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Lecture 10: PPP song Enzyme Regulation Why are enzymes activities regulated? How are enzymes regulated? Which enzymes are regulated? Many examples……. or Why do they do when they do?
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If you are converting carbohydrate into triacylglycerides, if you need pentose moeities to make nucleotides, You’ll find that Emden-Meyerhoff is not the game to play And you will do your biosynthesis the pentose phosphate way With transaldolase, transkelotase, G-6-P deH 2 , 6 times 6 gives 5 times 6 plus 6 of CO2, Carbons passing to and fro, the back becomes the front, Did you ever see a pathway like the pentose pathway shunt? First G-6-P is oxidized and NADP reduced To give gluconolactone as might as well have been deduced The lactone is then hydrolyzed to make the gluconate and Decarboxylation is its metabolic fate With transaldolase, transkelotase, G-6-P deH 2 , 6 times 6 gives 5 times 6 plus 6 of CO2, Carbons passing to and fro, the back becomes the front, Did you ever see a pathway like the pentose pathway shunt?
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There ends the oxidative phase, now multiply by three An intermediary balance sheet by way of summary Six NADPH are formed with 3 CO2 set free Three ribulose-5-P formed from 3 of G-6-P One isomerization from the ketose to aldose Turns ribulose-5-P to the phosphate of ribose Two of the three ribulose are epimerized inverted at C3 To xylulose-5-P from hence called Xu-5-P Two carbons from Xu-5-P transferred to the aldose Transketolase needs TPP as everybody knows Thus 3 plus 7 made to meet transaldolase attack 3 Cs from sedoheptulose the GAP gets back
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Glyceraldehyde-3-phosphate thus becoming F-6-P Leaves erythrose-4-phosphate looking for some company But Xu-5-P number 2 has two top Cs to spare Tranketolase negotiates their transfer as a pair So we’ve made another F-6-P, a triose-phosphate too To see what we have now achieved lets multiply by two Four F-6-Ps and two GAPs by glycolytic tricks Give 5 G-6-P where we started out with 6 With transaldolase, transkelotase, G-6-P deH 2 , 6 times 6 gives 5 times 6 plus 6 of CO2, Carbons passing to and fro, the back becomes the front, Did you ever see a pathway like the pentose pathway shunt?
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We must add an addendum, there’s recent work that shows A variant in liver cells involving octulose If you’ve just learned the classic path, you may think it’s a shame If it’s any consolation, the endpoint is the same! With transaldolase, transkelotase, G-6-P deH 2 , 6 times 6 gives 5 times 6 plus 6 of CO2, Carbons passing to and fro, the back becomes the front, Did you ever see a pathway like the pentose pathway shunt? Did you ever see a pathway like the pentose pathway shunt? Lyrics by Dr. Harold Baum !
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Concepts of Enzyme Regulation and Reciprocal Regulation AND Mechanisms for the Regulation of Enzymatic Reactions Why are enzyme reactions regulated?
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