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Lecture11powerpoint

Lecture11powerpoint - Hormonal Control of CHO Metabolism...

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Hormonal Control of CHO Metabolism and Fatty Acid Breakdown May 6, 2008
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Major concepts from last time Flux through metabolic pathways is controlled by regulating the activities of key physiologically irreversible enzymes (KPIE). KPIEs are typically at beginning of pathways, or near committed steps within pathways. Opposing pathways can function simultaneously, but not at the same rate (partial futile cycling). Partial futile cycling allows two points of control to achieve greater changes in flux (down-regulate and up-regulate KPIEs). Allostery and covalent modification regulate activities of KPIEs and in the case of CM, also the NZs that catalyze the modification and/or de-mod.!
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2 C Active Protein Kinase A AKA active cAMP-dep Protein Kinase (a serine/threonine kinase) Phosphorylase b kinase less active form Phosphorylase b kinase more active phosphorylated form ATP ADP ATP ADP ATP ADP ATP ADP Phosphorylase b less active form Phosphorylase a more active phosphorylated form Glycogen synthase I more active form glucose-6-P indep. Glycogen synthase D less active , phosphoryl. form glucose-6-P dep. High rate of Glycogen breakdown Slow rate of Glycogen breakdown H 2 O HPO 4 3- HPO 4 3- H 2 O Covalent Modification Regulates Mammalian Glycogen Metabolism in liver,muscle in liver,muscle Bifunctional PFK-2/F-2,6BPase
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