Jan 19 - Protein Synthesis Transport Transport pgs...

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Protein Synthesis Protein Synthesis & & Transport Transport pgs 535-42 (MC 534. 539, pgs 535-42 (MC 534. 539, 594), 594, 597-602, 606-612 594), 594, 597-602, 606-612
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Protein Problems & Human Diseases Diabetes Alzheimer’s Juvenile Parkinsonism Sarcomas Huntington’s ataxias Cystic Fibrosis Hereditary Emphysema Fabri’s Tay-Sachs Hypercholesterolemia Myeloid leukemia ALS Zellweger’s Syndrome Usher’s Syndrome The Traffic Jam Fried Egg Syndrome
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Two Major Organelles. Two Major Organelles. Endoplasmic Reticulum Endoplasmic Reticulum & & Golgi Golgi Two Major Concepts Two Major Concepts -i) Where are proteins made -i) Where are proteins made & subsequently modified? & subsequently modified? -ii) How are proteins -ii) How are proteins directed to specific regions directed to specific regions in cells? in cells? Both of which can contribute to traffic jam Camillo Golgi Nobel Prize 1906 Albert Claude Nobel Prize 1974
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Ribosomes Fig. 14-15
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ER (Structure/Function) -uninterrupted membranous tubules & vesicles separated from cytoplasm -RER has ribosomes on the tubules (cisterna) -cisterna are stacked -ER extend from nuclear membrane 13-2
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