Jan 25

Jan 25 - Where do proteins go after ER? Read pages 100-01...

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Where do proteins go after ER? R ead pages 100-01 how Pulse Chase is used to answer this question . Read 621-22 Sumanasinc.com George Palade 1974
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Golgi Complex -consists of flattened cisterna no ribosomes -vesicles at cisterna tips fuse or pinch off Types of Cisternae: i) trans -opposite RER ii) medial iii) cis - faces RER Cartoon of Fig. 14-15 Cis Golgi Network Trans Golgi Network
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Golgi Function : - “Scurvy” -sugars are trimmed from polypeptide -hydroxyl groups, added in RER, are used for folding -final synthesis/packaging for secretion Fig. 19-24 Chaperone Vitamin C
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Golgi also reroutes proteins back to RER or lysosomes How? - KDEL signal on proteins that should stay in RER lumen “Retention Signal” 14-13 anterograde retrograde coatamers
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will shuttle to Golgi -if it happens a KDEL receptor picks up Fig. 3-16 Proteins That Use Retention Signals. Chaperones - lumen proteins
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Jan 25 - Where do proteins go after ER? Read pages 100-01...

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