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1B - MT End Binding and Severing Proteins 3 mechanisms that...

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MT End Binding and Severing Proteins 3 mechanisms that can contribute to the destabilization of MT ends - binding of kinesin-13 (require ATP) - Stathmin binds tubulin dimers in the curve and may promote GTP hydrolysis - Katanin may release MTs from MTOCs
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Microtubules: Tracks for Transport Vesicle transport (bi-directional) Motor proteins require energy (ATP)
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Axonal Transport Squid axons are a model system. Labelled proteins travel at different speeds in cells (not diffusion). Fig 18-17
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Kinesin MT’s plus (+) end directed motor protein 14 known classes (45 genes in humans) 2 Heavy chains - head, flexible neck and stalk 2 Light chains (variable) Heavy chain heads have ATPase activity and MT binding ability Light chains recognize cargo MOST (+) directed
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Structures of Selected Kinesin Members.
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Kinesin, continued….. •  Anterograde movement ATP hydrolysis causes conformational changes in kinesin.
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