2A - Actin Filaments Microfilaments Cortical function Cell...

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Unformatted text preview: Actin Filaments - Microfilaments Cortical function. Cell shape and movement. Actin based structures Epithelial cells Migrating cells (and muscle) Networks and Bundles Actin: Structure Vertebrates isoforms – 4 α (muscle) β and γ G-actin (globular) polymerizes into F-actin (filamentous) microfilaments Actin: Polarity Polarity allows for independent regulation of actin assembly or disassembly (“decorated” with myosin S1) . Polymerization of actin filaments occurs preferentially at the (+) end Actin Assembly Actin polymerization and Critical Concentration Needed G-actin bound to ATP for polymerization Regulation of actin polymerization Thymosin sequesters actin and provides a reservoir. Profilin promotes actin polymerization by charging G- ADP into G-ATP actin. Cofilin enhances depolymerization. Cellular concentration of G- actin is 400 μ M, but Cc is 0.12 μ M – all should be polymerized Actin capping proteins - Block assembly and Disassembly CapZ binds to the (+) end and prevents growth,...
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This note was uploaded on 03/04/2010 for the course SCI 2290 taught by Professor Kraj,dean,z during the Spring '10 term at UWO.

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2A - Actin Filaments Microfilaments Cortical function Cell...

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