3 - - not globular no ATP or GTP needed -no polarity - no...

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- not globular – no ATP or GTP needed -no polarity - no known motor proteins Intermediate filaments
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Main types of intermediate filaments
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Intermediate filaments: structure The tetramer is the basic unit.
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IFs are in dynamic state Proteins within filament are exchanged
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Need to disassemble during mitosis – cyclin dependent kinase N-terminal domain of lamin A phosphorylated at serine residue - induces disassembly, and prevents reassembly - if serine residue is mutated no disassembly. Balance of opposing action of kinases and phosphotases crucial.
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Intermediate filament associated proteins Only organizational IFAPs identified (no motors, caps, severing). Plectin cross-link IFs (vimentin) and microtubules
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IF functions - membranes Lamins support nuclear membrane IFs provide structural support necessary for cell shape – eg. vimentin links to ankyrin Lamins A&B form network- linked to nuclear lamina through lamin associated polypeptides (LAP2) – an IFAP
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Keratin mutations Causes skin blistering –  weak skin integrity IFs anchored to  desmosomes and  hemidesmosomes 
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IF function - junctions IFs anchored to desmosomes and hemidesmosomes
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Cell Junctions and Cell Adhesion 4 types -Tight junctions -Gap junctions -Cell-cell adhesions -Cell-ECM adhesions
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Gap Junctions 6 connexins form a connexon Ca2+ regulated channel 19-18
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3 - - not globular no ATP or GTP needed -no polarity - no...

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