Lecture 3 Path II

Lecture 3 Path II - Lecture 3 Cancer Pathology II Medical...

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MCDB 3150 © B. B. Olwin, 2010 2010 Lecture 3 Cancer Pathology II Medical studies that defne the character oF cancerous tissues and the prognosis For a patient’s recovery MCDB 3150 © B. B. Olwin, 2010 2010 Lecture 2 Review The Cell Theory All living organisms are comprised oF cells Cells can only arise From other cells Cells replicate by cell division Tissues are generated by groups of cells that organize and specialize = differentiation 3 Germ layers: Endoderm, Ectoderm, Mesoderm Tumors are monoclonal Most cancers are carcinomas arising from epithelia Stem cells maintain and repair tissues 1 2
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MCDB 3150 © B. B. Olwin, 2010 2010 Important Concepts Stem cell: a cell that can self-renew and give rise to specialized progeny asymmetric division: a cell division where the daughter cells are different from each other and typically inherit distinct cell fates symmetric division: daughter cells are indistinguishable from each other commitment: a pathway to a specialized fate, often irreversible differentiation: state of specialized cell, typically postmitotic and often irreversible tumor: uncontrolled or abnormal growth benign: a tumor that has not penetrated the basement membrane malignant: an undifferentiated cell that exhibits uncontrolled growth and is invasive MCDB 3150 © B. B. Olwin, 2010 2010 Multicellular organisms are made of cells that organize to perform speciFc functions 3 4
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MCDB 3150 © B. B. Olwin, 2010 2010 How are tissues maintained and renewed? Stem cells thought to maintain and replenish tissues Stem cells may maintain more than one tissue Most stem cells are pluripotent and capable of differentiation into two different cell types MCDB 3150 © B. B. Olwin, 2010 2010 Stem Cell Fates 5 6
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MCDB 3150 © B. B. Olwin, 2010 2010 Stem Cell Fates asymmetric division asymmetric division Stem cells have versatility MCDB 3150 © B. B. Olwin, 2010 2010 The intestinal villi-a real example 7 8
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MCDB 3150 © B. B. Olwin, 2010 2010 Labeling of Stem Cells in the Intestine Label with
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Lecture 3 Path II - Lecture 3 Cancer Pathology II Medical...

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