4 SANES CH 4.1 only 2008 (1)

4 SANES CH 4.1 only 2008 (1) - Chapter 3 (dont panic, just...

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Chapter 3 (don’t panic, just a few final comments) Sanes, Reh and Harris Cell Division, Neuronal Birthdates, and Migration
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SINGLE GENE MUTATIONS and NEURONAL MIGRATION Many Possible Causes: For example: High level X-rays Toxins Experimental gene knock-out mutation of the reeler gene (gene product = “reelin” protein) causes serious deficits in neuronal migration in cortex and cerebellum and severe motor control problems. video.google.com/videosearch?q=reeler mouse&oe=utf-8&rls=org.mozilla:en-US:official&client=firefox-a&um=1&ie=U
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Reelin is a large glycoprotein produced by granule cells in the external granular layer where it acts as a signal to control Purkinje cell migration into a single layer. Reelin produced by the granule cells To resolve whether Reelin is attracting or giving a stop signal, we can study the events in the cerebral cortex The role of reelin in the development of cerebellar cell layers
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Normal wild type reelin expression by the Retzius- Cajal cells in layer I Reeler mouse: no reelin, inverted layers Wild type nestin/reelin: good migration Reeler with nestin/reelin expressed by radial glia: Good migration Reelin is important for neuronal migration: The exact source of reelin seems less important
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Sanes, Reh, and Harris Determination and Differentiation: How are neurons and glia specified to become what they become? and how do they differentiate into
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4 SANES CH 4.1 only 2008 (1) - Chapter 3 (dont panic, just...

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