{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

2 SANES CH 2 2009 + GI (2)

2 SANES CH 2 2009 + GI (2) - Development of the Nervous...

Info icon This preview shows pages 1–11. Sign up to view the full content.

View Full Document Right Arrow Icon
Development of the Nervous System Chapter 2 Polarity and Segmentation Sanes, Reh and Harris, 2nd Edition There are several important dimensions of polarity and specialization 1. Anterior-Posterior differentiation: brain to spinal cord 2. Dorsal-Ventral patterning: back to belly 3. Regional Specialization in the Cerebral Cortex Honor system: Stay home if you have a fever and think you have the flu
Image of page 1

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Initially the entire CNS starts as a single layer of neuroblasts that are formed into a tubular structure, the neural tube.
Image of page 2
Spina Bifida (myelomeningocele)
Image of page 3

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
No way adult How can gene expression program the changes necessary to make the brain develop at one end and the spinal cord at the other end?
Image of page 4
Control of anterior- posterior axis polarity is much better known in flies than in any other Species.
Image of page 5

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Homeobox genes were discovered in Drosophila around 1983 They are transcription Factors with an helical form composed of 60 a.a. domain and many names: Homeotic genes Hox genes Homeobox genes Homeodomain genes
Image of page 6
Located anterior = Bicoid + Hunchback mRNA Located posterior = Caudal + Nanos mRNA Regulate Regulate Gap genes oocyte Very early gene expression initiates segmentation in the embryo Hox genes are very important for instructing the anterior- posterior differentiation of the CNS
Image of page 7

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Flies and mice and us share homeobox-containing genes that control anterior-posterior development
Image of page 8
Drosophila ~14,000 genes Mouse = ~22,000 genes Human = ~30,000 genes Human Hox genes name chromosome gene [email protected] chromosome 7 = HOXA1, HOXA2, HOXA3, HOXA4, HOXA5, HOXA6, HOXA7, HOXA9, HOXA10, HOXA11, HOXA13 HOXB - [email protected] chromosome 17 = HOXB1, HOXB2, HOXB3, HOXB4, HOXB5, HOXB6, HOXB7, HOXB8, HOXB9, HOXB13 HOXC - [email protected] chromosome 12 = HOXC4, HOXC5, HOXC6, HOXC8, HOXC9, HOXC10, HOXC11, HOXC12, HOXC13 HOXD - [email protected] chromosome 2 = HOXD1, HOXD3, HOXD4, HOXD8, HOXD9, HOXD10, HOXD11, HOXD12, HOXD13 How do homologous genes become more precise and complicated?
Image of page 9

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
OLD, NON-SPECIFIC METHODS FOR GENE MANIPULATION: 1. X-RAY TESTICLES 2. GIVE TOXINS THAT CAUSE MUTATIONS News Nature 432, 541 (2 December 2004) | doi:10.1038/432541a; Published online 1 December 2004
Image of page 10
Image of page 11
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern