7 SANES CH. 7.1 only 2009

7 SANES CH. 7.1 only 2009 - Chapter 7 Sanes Reh and Harris...

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Chapter 7 Sanes, Reh, and Harris Naturally occurring neuronal death during normal development Part 1: pp. 173-192 November 29 is an interesting day: it is the day the first term papers are due
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What is the function of cell death in nature? Result of failure in cell death during development
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Programmed cell death visualized by pyknotic nuclei EM micrograph of dying neuron What does cell death look like? High mag of a WBC undergoing apoptosis Developing Kitten retina
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e.g., caused by stroke or trauma Programmed Cell Death (Apoptosis) vs Necrotic Cell Death: the basic difference is very important. e.g., occurs during normal development Nissl stained section from Chapter 5 powerpoint showing areas of necrosis: or is it PCD?
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TUNEL = Terminal transferase UTP Nick End Labeling (labelled nucleotide attached to the 3’-hydroxy end of DNA fragments) All Cells Apoptotic Cells EM image of TUNEL-positive neuron TUNEL in Newborn subventricular zone First publication using TUNEL was in 1992
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e.g., retinal support of LGN cells e.g., maxillary pad NGF Or NT-3 in pinna or muscle e.g., Schwann cells produce NGF during development and regeneration e.g., sex hormones arrive via the blood stream e.g., glial derived neurotrophic factor is a paracrine factor Influences on neuronal survival: trophic factors keep neurons alive 1 2 3 4 5
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Leg size at developing time points. The death of motor neurons occurs during the innervation of the leg muscles Lumbar Spinal Cord counts of normal MN Number of degenerating motor neurons Hughes, 1961 Takes about 3 hours to mop up a dead neuron 4,000 1,200
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Naturally occurring cell death is reduced when there is more target tissue to innervate: here on the sensory side with DRG cell death.
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This note was uploaded on 03/06/2010 for the course NSC 269 taught by Professor Ebner during the Spring '10 term at Vanderbilt.

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7 SANES CH. 7.1 only 2009 - Chapter 7 Sanes Reh and Harris...

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