CHEM162B_Midterm_Guide_B10

CHEM162B_Midterm_Guide_B10 - Chem 162/262 Final Exam Guide...

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Chem 162/262 Final Exam Guide Winter 2010 (Kahn) The midterm exam in Chem 162/262 will test your knowledge and understanding of topics covered up to, and including the molecular recognition and sources of ligand and macromolecular structures for virtual screening. Docking will not be covered on the midterm. You can demonstrate your knowledge by answering specific questions (e.g. draw a double-reciprocal plot illustrative of competitive enzyme inhibition). You can demonstrate your understanding by explaining what approaches and techniques are best suited to solve a particular drug design problem (e.g. how would you develop a transition state analog for chorismate mutase). Of course, understanding a topic requires good knowledge of the material. You should have a good knowledge of different enzyme mechanisms covered in the course but you are not required to memorize specific drug structures, names, or mathematical formulas. An old sample exam key is available at http://www.chem.ucsb.edu/~kalju/chem162/private/Exam_162_Key.pdf I believe that the following resources help you best in preparing for the exam: a) Lecture material. Was there anything that I said and was not clear? If so, please see if you can get answers by (i) listening to old course audio, (ii) asking me or (iii) reading the textbook/literature/Internet. b) Textbook provides a nice coverage on enzymes, interactions, and lead modification principles.
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This note was uploaded on 03/06/2010 for the course CHEM 162a taught by Professor Reich,n during the Spring '08 term at UCSB.

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CHEM162B_Midterm_Guide_B10 - Chem 162/262 Final Exam Guide...

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