BIO241_v22_with answers - Answer key 1D 8E 15 D 22 D 29 D...

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VERSION 22 Page 1 of 10 Answer key 1 D 2 A 3 B 4 D 5 D 6 A 7 B 8 E 9 B 10 D 11 D 12 C 13 C 14 A 15 D 16 C 17 C 18 D 19 A 20 B 21 A 22 D 23 E 24 E 25 A 26 D 27 D 28 D 29 D 30 D 31 E 32 C 33 D 34 D 1. Receptor-mediated endocytosis is a process by which plasma membrane receptors are internalized into cells via clathrin-coated pits. Which of the following events is specific to receptors that are destined to be degraded in the lysosome following endocytosis? a. Receptors bound to their ligand enter clathrin-coated pits. b. Receptors bind adaptor proteins of the clathrin coat. c. Receptors are transported to the early endosome with their bound ligand. d. Vesicles bud off inside the endosome carrying the receptors. e. Receptors are recycled back to the plasma membrane. 2. Which of the following proteins binds to activated G-protein linked receptors? a. GPCR kinase (GRK). b. Regulators of G protein signaling (RGS). c. Phospholipase C- β (PLC- β ). d. Adenylyl cyclase. e. Protein kinase A (PKA). 3. Signal amplification is an important aspect of signal transduction pathways. Which of the following statements is FALSE regarding the amplification steps following G- Protein linked receptor activation? a. Each G-Protein linked receptor can activate many G α subunits. b. Each G α subunit can activate many adenylyl cyclase proteins. c. Each adenylyl cyclase protein produces many cAMP molecules. d. Activation of one G-protein linked receptor leads to the synthesis of hundreds of cAMP molecules. e. cAMP molecules act as second messengers.
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VERSION 22 Page 2 of 10 4. Which of the following receptors is active in the absence of its ligand? a. Transforming Growth Factor β receptors. b. Cytokine receptors. c. G-protein-coupled receptors. d. Ethylene receptors. e. Erythropoietin receptors. 5. Which of the following statements is an example of secondary active transport? a. Transport of K+ down its electrochemical gradient by K+ leak channels. b. The generation of ATP by ATP synthase using a proton motive force. c. Using ATP hydrolysis to transport H+ against its electrochemical gradient. d. Using a proton motive force to transport Na+ against its electrochemical gradient. e. Transport of K+ and Na+ against their concentration gradients by the Na+/K+ pump. 6. Ran GTPase plays a critical role in the movement of proteins between the nucleus and the cytosol. Which of the following proteins preferentially binds Ran GDP (Ran GTPase bound to GDP)? a. NTF2. b. Nuclear import receptor. c. Nuclear export receptor bound to cargo. d. Empty nuclear export receptor (without cargo). e. Cargo with nuclear import signal. 7. What would be a predicted consequence of mutating the ER oligosaccharyl transferase to a non-functional form? a. Proteins would no longer be transported into the ER.
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This note was uploaded on 03/06/2010 for the course BIOLOGY BIO241 taught by Professor David during the Three '10 term at University of Technology, Sydney.

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BIO241_v22_with answers - Answer key 1D 8E 15 D 22 D 29 D...

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