BIPN 100, Mammalian Physiology I. Final Examination Page 1 Winter, 2006. March 21, 2006 Select the single best answer 1. Positive feedback loops ______________ and negative feedback loops______________. A. Cancel a change; keep physiological parameters constant B. Amplify a change; cancel a change C. Cancel a change; amplify a change D. Keep physiological parameters constant; cancel a change E. None of the above 2. GLUT transporters are: A. Never open to both sides of the membrane simultaneously B. An example of facilitated diffusion C. Gated channels D. Found on the apical side of the proximal tubule epithelium E. Both A and B 3. Which of the following molecules can cross a membrane by simple diffusion? A. Urea B. Aldosterone C. ADH D. Serotonin E. Only A and B 4. Which of the following sets of substrates is co-transported into the cells of the thick ascending loop of Henle ? a. Na + /Ca ++ b. Na + /glucose c. Na + /K + /2Cl d. Na + /H + e. Cl-/HC0 3-5. Which of the following sets of substrates is exchanged in the sarcolemma of myocardial cells? a. Na + /Ca ++ b. Na + /glucose c. Na + /K + /2Cl d. Na + /H + e. Cl-/HC0 3-6. Which of the following sets of substrates is co-transported into the cells of the proximal kidney tubule? a. Na + /Ca ++ b. Na + /glucose c. Na + /K + /2Cl d. Na + /H + e. Cl-/HC0 3-
BIPN 100, Mammalian Physiology I. Final Examination Page 2 Winter, 2006. March 21, 2006 Select the single best answer 7. Which of the following are true about Na+/K+ pumps? I. They do not contribute to repolarization of the membrane during an action potential. II. They move 3Na+ into the cell and 2K+ out of the cell III. The pump must be phosphorylated to release K+ inside cells IV. They generate electrochemical gradients for secondary active transport V. They are only located in the basolateral membrane of transport epithelial cells. a. I, II, III, V only b. III, IV, V only c. I, IV, V only d. I and IV only e. All of the above 8. Which of the following is NOT TRUE about ion movements across membranes? A. The electrical potential necessary to counteract an ion’s concentration gradient can be calculated with the Nernst equation B. Net ion flow through a membrane depends on both the permeability of the membrane to that ion and the driving force on that ion C. The Goldman equation reduces to the Nernst equation if the membrane is permeable to only one type of ion D. The driving force on an ion can be calculated with the Goldman equation E. It is possible for ions to flow passively through a membrane against their concentration gradient The following two questions are based on data below for an alien neuron. Assume Vrest = +60 mV, temperature = 30C Ion: Inside concentration (mM) Outside concentration (mM) Na+ 14 140 Ca++ 0.001 1.0 Cl-15 150 Br-100 10 9. What is the Nernst equilibrium potential for Calcium? a.
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