GDCB511 Homework_YANG 4_22_09

GDCB511 Homework_YANG 4_22_09 - XPV gene, including intron...

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GDCB 511, Homework 4: due Wednesday April 29, 2009 Reading material: Masutani, et al, 1999. The XPV (xeroderma pigmentosum) gene encodes human DNA polymerase η . Nature, 399(7): 700-4. Questions: please answer the following: 1. What are the evidences for the authors to claim that Hela DNA polymerase eta possesses an error-free lesion-bypass activity? 2. With availability of human genome sequence, please draw a schematic diagram of
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Unformatted text preview: XPV gene, including intron and exon. How do you explain the multiple bands of the Northern blot of Fig. 2? 3. For Fig. 4C, why the authors included purified DNA polymerase alpha in the experiment? What was the conclusion from this figure? 4. How can you explain the relative low sensitivity of XP-V cells to ultraviolet radiation compared to other forms of XP?...
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