GDCB 511-4-29-090

GDCB 511-4-29-090 - GDCB 511, April 29, 2009...

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Announcements 1. Homework assignment is due today. 2. A comprehensive review will be held Friday May 1. 3. The exam 4 (7:30-8:30) and final exam (8:30- 9:30) are on Tuesday May 5. GDCB 511, April 29, 2009 Retrotransposition
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Fig. 23.16 Nicking of opposite strands occurs at RSSs at the junctions between coding regions (red) and intervening segments (yellow). The 3’ OH groups that are released attack the opposite strands forming hairpin loops on the coding segments. The intervening sequence is lost from the cell. The hairpins open and the two coding regions are joined together in an imprecise fashion.
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Fig. 23.17
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Rag1 and Rag2 are transposases that mediate immunoglobulin gene rearrangements
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TE class Retrotransposons Retrotransposons and Retroviruses: Both replicate through an mRNA intermediate. The mRNA is copied to cDNA and then integrated into the genome by the protein integrase. Integrase and transposase carry out the same fundamental chemical reaction.
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Retroelements: Retroviruses and Retrotransposons HIV: Human Immunodeficiency Virus
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Retroviruses
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GDCB 511-4-29-090 - GDCB 511, April 29, 2009...

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