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Final Study Guide

Final Study Guide - Vandan Desai Section 201 Biology 100...

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Vandan Desai Section: 201 1 Biology 100 Lab—Final Study Guide I. Lab #5: Bioinformatics A. Information: i. Know what you can do with Bioinformatics —unknown species identification, find function of new genes by comparison to known genes in other species, trace origins of man, evolutionary relationships b/w species, measure genetic diversity in populations of endangered species Medical Applications —diagnose human genetic disease, predict genetic susceptibility to non-genetic disease, designer drug, rational drug design using 3-D protein structures, gene therapy ii. Know where you would go to find the following information: Amino acid sequences Genbank %ucleotide sequences— Genbank Taxonomic information Genbank, TaxBrowser Properties of human genes— OMIM Properties of genes in other animals— Genbank Biomedical journal articles PubMed iii. List several types of information available from the %CBI homepage —all of one’s listed above B. Vocabulary: i. Bioinformatics —the application of computer technology to the management of biological information An intellectual discipline Goal —gain understanding about living things Method —use computers to search for informative patterns in protein and nucleotide sequence databases ii. Human Genome Project —responsible for recent explosion of publicly available genomic information and the need for Bioinformatics An international research initiative Launched in 1990, completed 1 year ahead of time in 2003 Primary Goal —determine the nucleotide sequence of entire human genome (3 billion base pairs) Satellite Goals —sequence complete genome of select non-human genome First Complete Genome —bacterial pathogen ( Haemophilus influenzae )—1.5 billion base pairs Others —228 sp. of bacteria, insects, yeast, fungi, mammals, plants, etc. iii. %CBI —National Center for Biotechnology Information; established in 1988 as a national source for molecular biological information Creates public-access databases, Develops software tools for analyzing genome data, and Disseminates biomedical information to get better understanding of molecular processes affecting human health and disease iv. Entrez —search and retrieval system that integrates the nucleotide sequences, protein sequences, macromolecular structures, whole genomes, and scientific literature
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Vandan Desai Section: 201 2 Benefits —all of these databases are linked to each other One may easily access a protein sequence, obtain literature on that protein, examine clinical disorders resulting from defect in the protein, and analyze the chromosomal location of the gene, all with the click of a button v. Genbank —DNA sequence database; contains over 9,103,000 nucleotide sequence records as of October 2000 Uses —nucleotide sequences (all organisms), amino acid sequence (all organisms), taxonomic classifications of source organisms, and annotations
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Final Study Guide - Vandan Desai Section 201 Biology 100...

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