MCB110 – Nogales – Spring 2000 STUDY QUESTIONS III C ELL S IGNALING What type of receptors interact with trimeric G proteins? How does binding of a ligand to a G-coupled membrane receptor result in activation? What is required for the α subunit to reassociate into the trimer? Contrast the roles of GAPs, GEFs and GDIs in the G protein cycle How is cAMP concentration regulated in the cell? How does activation of PKA lead to alterations in glucose metabolism? Why several steps of phosphorylation result in amplification of the signal in a given signaling pathway? How is the signaling of epinephrine terminated? What are the proteins and regulatory mechanisms involved? What are the precursors of PIP2? What are the products formed when phospholipase C hydrolyses PIP2? Review some of the mechanisms by which the concentration of Ca 2+ is regulated in the cytosol? In a few words, what is the mode of action of calmodulin?
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This note was uploaded on 03/08/2010 for the course MCB 110 taught by Professor Alber,zhou,nogales during the Fall '07 term at University of California, Berkeley.