More NMR - CFQ & PP: Other NMR Topics Reading Brown and...

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128 Reading Brown and Foote: Sections 13.12, 13.13 and Chemistry in Action Box page 475 Lecture Supplement Other NMR Topics (Page 34 of this Thinkbook) Optional Reading from the Scientific Research Literature "Tumor Detection by Nuclear Magnetic Resonance" R. Damadian, Science , 19 March 1971, p. 1151 - 1153 (This paper announces the discovery of MRI.) Suggested Text Exercises Brown and Foote: Chapter 13: 8, 9, 16, 17, 28, 30, 32 Chapter 17: 17 Chapter 20: 23, 24, 29, 30 Optional Interactive Organic Chemistry CD and Workbook 13 C-NMR (p. 56) The table of characteristic 13 C-NMR chemical shifts included in the lecture handout does not need to be memorized. Working lots of problems will help you become familiar with the numbers. The data will be given on an exam if needed. More problems in which structures are deduced from 13 C-NMR spectra can be found Concept Focus Questions 1. Clearly and concisely define each of the following terms. 2D-NMR DEPT Relaxation time COSY MRI 2. What is the nuclear spin quantum number of a nucleus that can be observed by NMR? 3. Why does NMR easily observe 19 F and 31 P while 13 C is more difficult? 4. Describe the sequence of events that occurs within the Fourier Transform NMR (FT- NMR) spectrometer that result in an NMR spectrum. 5. Recall the four fundamental types of structural information derived from a proton NMR spectrum. Discuss these same information types in carbon NMR. 6. What basic carbon types are found in the following NMR shift ranges: 0 - 80 ppm, 100 - 160 ppm, 160 - 210 ppm. 7. What fundamental information is obtained from a 2D-NMR spectrum?
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CFQ & PP: Other NMR Topics 129 8. Describe a typical 2D-NMR spectrum. How is this spectrum interpreted? 9. What nuclear property does MRI utilize? How does this property lead to medical images? Concept Focus Questions Solutions 1. 2D-NMR: Two-dimensional NMR. An NMR technique used to examine the interaction (e.g., spin coupling) of nuclei with a molecule. COSY: CO rrelation S pectroscop Y . A 2D-NMR technique in which the spin coupling of protons are examined. DEPT: D istortionless E nhancement of P olarization T ransfer. A carbon NMR technique used to determine the number of protons attached to carbon atoms. MRI: M agnetic R esonance I maging. An NMR technique in which the relative relaxation times of protons is used to image structures of medical interest. Relaxation time: The time required for nuclei to return from the excited to the ground nuclear spin state. 2.
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More NMR - CFQ & PP: Other NMR Topics Reading Brown and...

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