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Organic Synthesis - CFQ PP Multi-step Organic Synthesis...

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74 CFQ & PP: Multi-step Organic Synthesis CFQ & PP: Multi-step Organic Synthesis Reading Brown and Foote: Sections 10.10 Appendix 7: Reagents and Their Uses Appendix 8: Summary of Methods for the Synthesis of Functional Groups Lecture Supplement Multistep Organic Synthesis (page 9 of this Thinkbook) Optional Web Site Reading The 1990 Nobel Prize in Chemistry (http://www.nobel.se/chemistry/laureates/1990/ index.html) Review Topics to review from Chem 30A, as needed: S N 2/S N 1, elimination, radical halogenation, addition to carbon-carbon π bonds Suggested Text Exercises Brown and Foote: Chapter 8: 46, 50 Chapter 9: 41, 43, 46 Chapter 10: 6, 19 - 31 Chapter 11: 32 - 39 Miscellaneous Projects Create reaction flash cards (Brown and Foote Appendix 8 very useful for this!) Concept Focus Questions 1. Define "retrosynthesis." 2. Describe the retrosynthesis process used to design a multi-step organic synthesis. Use the example shown below. Convert into O H Concept Focus Questions Solutions 1. Retrosynthesis is the process of thinking backwards in synthesis design. We consider how a given target molecule is made from some precursor molecule, instead of starting with the given starting material.
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