XRay - CFQ & PP: X-ray Crystallography Reading None...

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162 Reading None Lecture Handout X-ray Crystallography (page 43 of this Thinkbook) Optional Web Site Reading 1985 Nobel Prize in Chemistry (www.nobel.se/chemistry/laureates/1985/index.html) Crystallography 101 (http://www-structure.llnl.gov/Xray/101index.html) Suggested Text Exercises None Concept Focus Questions 1. Briefly describe at the atomic level the events that lead to an x-ray diffraction pattern. 2. For what significant contribution to x-ray crystallography were Sir William Henry Bragg and Sir William Lawrence Bragg awarded the 1915 Nobel Prize in Physics? Hint: Search the Nobel Prize web site (http://www.nobel.se). 3. How did Rosalin Franklin's x-ray diffraction data guide Watson and Crick to the correct structure for DNA? 4. What is the single most significant advantage and disadvantage of x-ray crystallography as a tool for structure determination? Concept Focus Questions Solutions 1. The electron cloud surrounding the atoms in a crystal diffracts a beam of x-rays. Atoms with larger number of electrons diffract a greater number of x-rays and are thus more easily detected. The position of the diffracted x-rays is determined by a detector, the type of which depends upon the design of the x-ray diffractometer (the instrument used to measure x-ray diffraction patterns). If the x-rays that impinge upon the detector arrive in phase, they interfere constructively (their amplitudes add). If they arrive out of phase, the amplitudes subtract (destructive interference).
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XRay - CFQ & PP: X-ray Crystallography Reading None...

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