CH369.lecture5 - Chymotrypsin Case Study of an Enzyme What...

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Chymotrypsin Case Study of an Enzyme
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What Is an Enzyme? A catalyst that accelerates the rate of chemical reaction . Mostly made of proteins. Recently, some RNA (ribozyme) has been found to have catalytic activities.
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Enzyme catalyzed reactions The enzymatic reaction is carried out in a specific location of enzyme known as the active site Enzymes apart from nonbiological catalysts is their reaction specificity, i.e., most enzymes are highly specific for their substrates and products More than one protein may catalyze a given chemical reaction. These enzymes are called isozymes.
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All biochemical reaction: Addition of one substrate to another Removal of a group Rearrangement
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Nomenclature An enzyme is named by incorporating the suffix - ase into the name of its substrate; e.g., enzyme that cleaves peptide bonds is called protein ase , a prote ase , or a peptid ase Most enzyme names contain more descriptive words for its catalyzed reaction (also end with –ase)
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Nomenclature Enzyme names indicate catalyzed reaction e.g., pyruvate decarboxylase Alanine aminotransferase
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Amino acid side chains Cofactor – a tightly bound molecule to the enzyme, such as metal ion in oxidation-reduction reaction, heme in hemoglobin and myoglobin. Coenzyme – organic molecule cofactors,
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This note was uploaded on 03/09/2010 for the course CH 369 taught by Professor Kbrowning during the Spring '07 term at University of Texas at Austin.

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CH369.lecture5 - Chymotrypsin Case Study of an Enzyme What...

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