CH369.lecture6 - Steady-state Steady-state enzyme kinetics...

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Unformatted text preview: Steady-state Steady-state enzyme kinetics enzyme kinetics Therapeutic Drugs Therapeutic Drugs • Efficacy – ID 50 , IC 50 • Potency – dosage • Pharmacokinetics – Drug metabolism – toxicity Which statement(s) is (are) true? A.The more catalyst present, the faster the reaction. B.As product is formed, substrate concentration decreases. C. Substrate utilization is dependent on product formation D. A and B E.A, B, and C Progress of the triose phosphate Progress of the triose phosphate isomerase reaction isomerase reaction E+S E+S ES ES E + P E + P The equations of chemical The equations of chemical kinetics kinetics Consider a Unimolecular reaction A B Rate constant [ ] [ ] d A dt v k A = - = k is the rate constant The equations of chemical The equations of chemical kinetics kinetics For a bimolecular reaction A + B C The rate constant [ ] [ ] [ ][ ] d A d B dt dt v k A B = - = - = k is a second-order rate constant. Rate equation for an enzyme- Rate equation for an enzyme- catalyzed reaction catalyzed reaction 1 2 k k E S ES E P + ←→ → +-1 The rate for product formation is [ ] 2 [ ] d P dt v k ES = = The velocity of the reaction = the rate of The velocity of the reaction = the rate of appearance of the product appearance of the product Experimental conditions for steady state kinetics a) [S] >> [E] b) [ ] d ES dt = Steady-state At steady state of a reaction,...
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  • Spring '07
  • KBrowning
  • Enzyme inhibitor, HIV Protease, inhibition Noncompetitive inhibition, Therapeutic Drugs Therapeutic Drugs, inhibition Allosteric inhibition

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