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CH369.lecture12 - Pasteureffect His discoveries reduced...

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Pasteur effect His discoveries reduced mortality from puerperal fever , and he created the first vaccine for rabies . His experiments supported the germ theory of disease . He was best known to the general public for inventing a method to stop milk and wine from causing sickness, a process that came to be called pasteurization . Louie Pasteur
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Pasteur effect
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Pasteur effect
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Pasteur effect Rate of glucose consumption by yeast cells decreased dramatically when the cells were shifted from anaerobic to aerobic growth conditions.
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The Warburg effect (W) More aggressive cell line, MDA-MB- 231, has much higher glucose consumption in the presence of oxygen than the MCF-7 cells with a non-invasive phenotype. Basis for PET
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Under anaerobic condition - glycolysis. -2ATP + 4ATP _______ Net: 2ATP
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__________     38 ATP Under aerobic condition CAC
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The Citric Acid Cycle Is Both  Catabolic and Anabolic Six of the eight citric acid cycle intermediates (all except isocitrate and succinate) are precursors or products of other substances
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Citric acid cycle intermediates as biosynthetic precursors amino acids
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α -ketoglutarate to glutamine
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Transamination reaction G ~ 0
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Anaplerotic reactions of the citric acid cycle
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The citrate transport system.
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