CH369.Lecutre3 - Structure of DNA 5 3 3 5 The two strands...

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Structure of DNA
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5’ 3’ 3’ 5’ The two strands of DNA re anti-parallel; Phosphate-ribose backbones are outside, ases are inside of the duplex
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Interactions between the bases on the two DNA strands – Hydrogen bonds
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X-ray diffraction analysis Rosaline Franklin and Maurice Wilkins - DNA is uniform helical; - It has 10 base pairs per turn; - It’s symmetrical around the short axis 3.4A 34 A
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DNA structure determination – putting pieces of the puzzles together. Erwin Chargaff: Chargaff ratio: The four nucleotides in are not always equivalent, yet A=T G=C
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Double Helical DNA James Watson Francis Crick 5’ 3’ 3’ 5’ 180
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DNA structure (B-form) Major grove Minor grove 20 Å 34 Å 10 bp .The two strands of DNA are anti-parallel; . The DNA helix is twisted in the right handed fashion; . The diameter = 20 Å; .There are two unequal grooves, he major and minor groove; .Sugar-phosphate backbones are on the outside; .Bases are at the center of the helix; .Bases are stacked on top of each other .Base pairing provides a mechanism for DNA replication
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RNA structure RNA is single- stranded nucleic
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This note was uploaded on 03/09/2010 for the course CH 369 taught by Professor Kbrowning during the Spring '07 term at University of Texas.

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CH369.Lecutre3 - Structure of DNA 5 3 3 5 The two strands...

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