1. Describe how transcription and translation can be coupled in prokaryotic cells. What is the advantage of coupling transcription and translation in a prokaryotic cell? Why are transcription and translation not as directly coupled in eukaryotic cells? It’s like a one room workshop. As soon as the transcript of RNA peels away from the DNA template, polyribosomes can start translating. The advantage is speed? These aren’t coupled in eukaryotic cells because we have RNA processing that takes place. 2. What is a "point mutation" and do they occur in DNA or RNA? How are missense and nonsense mutations different? Sickle-cell disease is an example of what can happen with a base pair substitution (a point mutation). How does this substitution change the normal gene product? What does the term "frameshift" mean with regard to RNA transcription? How can a deletion or insertion (also types of point mutations) cause a frameshift mutation? Point mutations occur in DNA. Missense mutations involve changing an amino acid, and thus changing the primary structure of a
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This note was uploaded on 03/09/2010 for the course BIOL 1201 taught by Professor Wishtichusen during the Spring '07 term at LSU.