380 10 Lec 3

380 10 Lec 3 - Biology 380 Immunology Lec. 3: Innate...

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Biology 380 Spring 2010 Immunology Henson Lec. 3: Innate Immunity II 1. The inflammatory response is fundamentally innate in nature. A. Macrophages and neutrophils are professional pathogen killers. a. Have surface receptors that recognize pathogens. b. Pathogens undergo phagocytosis and are killed by specific mechanisms. c. Neutrophils (and Eosinophils) trap bacteria in DNA nets. d. Exit the blood stream by the process of extravasation mediated by lectins. - Video = Inner Life of a Cell B. Macrophages release cytokines that modulate the inflammatory response. a. Important cytokines include TNF- α , IL-1, and IL-6. b. Generate fever response, release of acute phase proteins, increased vascular permeability, and neutrophil and lymphocyte extravasation. - These cytokines have a dark side = septic shock 2. Complement a proteolytic cascade of serum proteins that “complement” the actions of antibodies. A. Early experiments showed:
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This note was uploaded on 03/09/2010 for the course BIO 380 taught by Professor Henson during the Spring '10 term at Dickinson.

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