{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

380 10 Lec 3

380 10 Lec 3 - Biology 380 Immunology Lec 3 Innate Immunity...

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
Biology 380 Spring 2010 Immunology Henson Lec. 3: Innate Immunity II 1. The inflammatory response is fundamentally innate in nature. A. Macrophages and neutrophils are professional pathogen killers. a. Have surface receptors that recognize pathogens. b. Pathogens undergo phagocytosis and are killed by specific mechanisms. c. Neutrophils (and Eosinophils) trap bacteria in DNA nets. d. Exit the blood stream by the process of extravasation mediated by lectins. - Video = Inner Life of a Cell B. Macrophages release cytokines that modulate the inflammatory response. a. Important cytokines include TNF- α , IL-1, and IL-6. b. Generate fever response, release of acute phase proteins, increased vascular permeability, and neutrophil and lymphocyte extravasation. - These cytokines have a dark side = septic shock 2. Complement a proteolytic cascade of serum proteins that “complement” the actions of antibodies. A. Early experiments showed:
Background image of page 1
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

Ask a homework question - tutors are online